1. MacBook 12" 2015 feels dramatically faster at 1x scaling vs. 2x, even with the same output resolution (2560x1440@1x vs. 1280x720@2x.)
2. Mac with 8GB RX 580 GPU. With >1x scaling, as I add load (i.e. Chrome tabs) it eventually runs out of GPU memory and starts paging to system RAM. The whole thing grinds to a halt at that point.
The rendered pixel count makes this effect worse -- dual 4ks are slower than a 5k, is slower than a single 4k, is slower than dual HDs. This is to be expected, but we're talking about an 8 gigabyte GPU, and the framebuffer sizes should be a tiny drop in the bucket.
None of this happens at 1x scaling. Running a native (2x) scale factor feels a little faster than a downscaled (2x -> 1.5x) scale factor.
As far as I can tell, load and GPU mem usage scales with:
(number of GPU applications * total rendered pixels) ^ k.
At 1x scaling, k is close to 1. At HiDPI, it's greater than 1.