Runtime detection is the process querying what extensions are available, and then selectively using those. You adjust what the query returns to only return the common set.
Runtime detection has been a pretty standard thing for well over a decade now - it's how we all manage to run the same compiled binaries over the years despite variability in SSE & AVX support. You don't download different versions of Chrome/Photoshop/Gimp/Premiere/Blender/Whatever compiled for different CPU micro-architectures, do you? You might if you run Gentoo I suppose, but that'd be about it.
> Does it mean that I can’t compile with -mavx2 anymore?
You already can't if you're shipping binaries to users unless you only support Skylake & newer? There's a lot of CPUs currently in use that don't support AVX2. So... you either already have this problem and you're familiar with it, or you're not doing this and it's moot.