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> unintended consequences

That is a rare thing for me these days with uBlock Origin. I assume you're referring to broken websites when using ad blocking.

I never really used an adblocker as well, but now I'm using nextdns which does really good filtering at the dns level (not affiliated).

What unintended consequences?

Sometimes checkout on storefront sites will rely on scripts served from domains that adblockers block. When this happens, it's easy enough to turn the adblocker off for a few minutes (or, conversely, to decide "nope I'm not shopping here").

Adblockers broke EasyJets navigation on their website, I think they have since fixed it.

Weird formatting, things not working and you not remembering/understanding why, trying to keep settings in sync across browsers and platforms, and so on.

IOW I've found it easier to tolerate ads and slow sites "functioning as intended" than the much-less-frequent but far-more-maddening broken functionality that takes me "longer than it should" to troublehsoot.

I'm not sure I've used uBlock though, mostly ABP over the years.