However, the number of websites where a full-blown library like React is the right tech stack is probably less than 5%. For everyone else you would want to use vanilla JS, though if you are already familiar with jQuery I don't think there is anything wrong with using it.
The funny thing is I spent years using jQuery and have also used Vue.js, but I'm just so tired have having to deal with importing libraries, setting up build systems, etc. that 9 times out of 10 I will just use vanilla HTML/CSS/JS and call it a day. It is just so much simpler. YMMV