But a Mac's interface is not an iOS interface. There are different constraints and different best practices, and sometimes completely different widgets. To make a decent UI, you have to understand the native platform.
I think the same thing occurs on the desktop. Many times I use iPad applications and wish they were available on the desktop. iPad applications especially I think can work very well on the desktop due to the large display.
But don't take my work for it. Have a look at the streamtome app on the mac app store. The interface mimics that of the iPad. I am not sure if it uses chameleon but there's a good chance I would guess.
The ability of a stopgap measure such as this is a good way to let established iOS players test the Mac waters without a huge investment.