When I code I notice a few things about the multimonitor setup. My cursor can travel 10 physical feet of screen space and it's literally inefficient to point. The ergonomics are terrible. The entire setup basically feeds inattention and an ever-sprawling amount of crap being opened. More than that I think having multiple large rectangles shooting light into your eyeballs kind of screws with your circadian rhythms.
When I code I use a laptop and enjoy how briefly my hands leave the keyboard before returning because what little pointing i'm doing can be done extremely quickly because of the small size of my workflow. Bigger is better is oversold - a workspace should match the work - too small is just more common than too big.