What an interesting thing to take away from the quote, maybe I assume too much because I've read the whole speech but certainly I did not think he meant to say what you are implying.
What I took from it personally is that people tend to find meaning in life from something - a deity, a job, money, fame, looks, their own business - and that it doesn't really which of those you choose you're essentially taking a leap of faith that it will deliver happiness.