When/how will this be exploited by the "designer drugs"/"research chemicals" community to start a drop-shipping psychoactives business?
What is an "approved" drug development? Who gets to decide, when the substances are not restricted or scheduled? This means making them is not illegal. So I fail to see how it is an "unfortunate risk", except a risk of making money- which would be fortunate :)
You are missing opportunities just due to your specific moral stance. Drop-shipping is an excellent way to have new customer acquisition pipelines without having to pay for them.
Though please do correct me if I'm missing the use case you are referring to.
I think you may be throwing the baby with the bathwater, as designing and improving designer drugs is an untapped market with far more potential upsides than downsides.