That said, in order to support `eval` and friends, you still need a full-fat compiler in the browser. So the best route is probably to use a full-service Python->JS compiler, but compile most of the code ahead of time. That's where we're heading with Anvil (we use https://skulpt.org for the client side, but it's the same principle).
My colleague wrote up a pretty wide-ranging comparison of browser-based Python interpreters. It describes how (and why) Brython, Batavia, Skulpt, Transcrypt, and Pyodide differ, and the tradeoffs they're chasing: