Specifically where I run into it a lot is installing python modules that expect glibc to build something from source. The workaround is to either install the python module from the alpine package manager (apk) or to add in glibc to alpine.
90% of what programming I do is in C/Rust/sh, so I shouldn't run into that. Thanks for the heads up though, I'll keep it in mind when I do use python, which makes up a good chunk of that last 10%.