edit: This explains it a bit
> When you insert a new row with a random primary key value, InnoDB has to find the page where the row belongs, load it in the buffer pool if it is not already there, insert the row and then, eventually, flush the page back to disk. With purely random values and large tables, all b-tree leaf pages are susceptible to receive the new row, there are no hot pages. Rows inserted out of the primary key order cause page splits causing a low filling factor. For tables much larger than the buffer pool, an insert will very likely need to read a table page from disk. The page in the buffer pool where the new row has been inserted will then be dirty. The odds the page will receive a second row before it needs to be flushed to disk are very low. Most of the time, every insert will cause two IOPs – one read and one write. The first major impact is on the rate of IOPs and it is a major limiting factor for scalability. [1]
1: https://www.percona.com/blog/2019/11/22/uuids-are-popular-bu...