They did not apply social engineering to a random set of Twitter employees. Simply identifying this select subset of employees indicates sophistication.
I also highly doubt normal Twitter employees can impersonate any users. I would seriously hope it's less than 100 people with the DB or server access necessary to tweet as someone they don't have auth credentials for.
Edit: "We detected what we believe to be a coordinated social engineering attack by people who successfully targeted some of our employees with access to internal systems and tools."
https://twitter.com/TwitterSupport/status/128359184646423347...
Which makes it really concerning, Twitter can essentially impersonate the President and influence the markets, start a war, etc