Will people like your game if it's ugly?
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It is definitely much easier to draw people into playing your game if it looks nice/has a cool and cohesive aesthetic (the 6-second GIF heuristic mentioned in the top-comment), but if your game is a major success in other ways, it can be a hit despite what it looks like. But that doesn't mean you should neglect the aesthetics: part of getting something to be popular is removing as many of these "despites"/barriers-to-entry as possible.