In my circle of friends who do usually work remote, there are a few that want to move to more rural areas. The number one concern is availability of broadband, which is just terrible in Germany. Further down is friends/family not being close and possibly sticking out very much. I don't think remoteness is an actual issue (because there really isn't remoteness anywhere in Germany, it's very densely populated, and saving a lot on rent & co might well offset the cost for a few hours of driving every other weekend to meet friends.