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For a truly lowest latency in software application you need to avoid all context switches. Using interrupt driven IO adds to much overhead. You need to use polling and busy waiting. I'm working on a guide for this type of application design. If you are indeed using the Linux network stack, then yes adjusting NIC interrupt coalescing and interrupt affinity is useful.

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True, but you have to rewrite your application to switch to a receive queue polling model, whereas "tuning" is stuff you can get for free with your existing program.

I've always been using kernel bypass for low latency networking. You can also use SO_BUSY_POLL with the Linux stack. I should at least mention this in the guide.

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