If you're in the public sector, or have customers in the EU or Australia, you might get sued or fined if your app isn't accessible.
Weirdly even in the US you might not be in the clear for internal tooling. My understanding is its illegal to refuse to hire a blind person because they're blind. If you hire someone who's blind and they can't do their job because your internal tools are written in Godot, you might be leaving yourself open to discrimination suits. Not a big deal when you're a startup, but it will matter at google / fb / etc. I'm sure google has blind employees today who care a great deal about being able to do their jobs.
That sounds like a legal minefield, with more mines added over time.
In short, if you aren't making a video game or a toy, it seems like good advice to use tools that work with accessibility.
(I am not a lawyer. This is not legal advice.)