For an average web developer, someone just getting into django, or someone who isn't yet running into the limitations that the author apparently is, this is a recipe to just make a huge mess.
It's also very specific advice. Recommending ignoring cross-database concerns.. I'm sure that's fine if you're an end-user developer building and running your own product, but if you're considering writing a library or reusable app you'd like to be useful to other django users, it's probably worth a second thought.
It's ironic though that the author makes such a prominent mention of "You Ain't Gonna Need It", because that's exactly what I'd say about most of the pimped-up tweaks mentioned here. 99% of people aren't going to run into these limitations and will produce a much more maintainable app by following the standard django doctrine.