As someone who works on libraries that don't use JSX, and therefore have to rely on compiler and linter plugins to get support (tagged template literals in my case) I worry that React's dominance will mean that it gets a place in Rome, while other systems are locked out, which only increases React's dominance.
Would you consider an internal plugin system as a first step, where plugins have to be part of the codebase, but intentionally get a restricted API surface? This would allow you to try out and refactor the plugin API over time before committing to it publicly.