The last American urban exodus started in the 1950s and wasn't fully reversed until the early 2000s.
Many cities never recovered in the Mid-Atlantic and Midwest. Even the most expensive cities, like San Francisco, LA, and New York, had neighborhoods that were run down and dilapidated, ignored for decades, until very recently.
I'm not saying this will necessarily happen again, but it certainly could. Cities are incredibly expensive to maintain, and most American cities have already spent their "rainy day" funds in just a few months of lock-downs. All the while depolicing is gaining steam.