I talked down one or two people from completely destroying their environment while in such a state, by using deliberately de-escalatory calming techniques.
I’m aghast the police would use such a substance because it is indeed a recipe for disaster when mixed with their expectations of behavior.
I really doubt the club kids to saw had taken anything like the equivelant of 300mg or 500mg taken IM (2x the bioavailability of intranasal), or even intranasally. If you are standing, 50-75mg taken intranasally can cause transient, trance-like states like you describe. 100mg taken intranasally (50g IM equivalent) is enough such that most people couldn't safely walk, and would have closed-eye visuals almost like a lucid dream. 150mg intranasally will guarantee a k-hole for most people, and 300mg plus would render all but those with extreme tolerances unconscious.
I should also add that the ones whom I had to talk down were probably also on heaven-knows what other substances at the time.
All I can say for what I did at the time was an intuition that I was confronted with a half-tranquilized, large confused ape and so acted as to prevent them from panicking and running amok with calm words, movements, and (most importantly I suspect in that state) caring touch.