You should check out Rocksmith. Its guitar hero with real guitar, pretty cool stuff. I don't see how a scrolling format like guitar hero would fit the slow refresh rate of an e-ink display, but perhaps you imagine something different.
Absolutely love that toy, unfortunately they stopped producing DLCs for it some time ago to do something else... I wonder what that is.
Custom DLC is still going strong
They are working on RockSmith 2, you don't know this from me.
I remember a couple years ago getting Rocksmith for my ps4 and absolutely loving it. The controller mappings were a little unnatural in places but I did reasonably well with reading their notation/tab. Fast forward to when I tried to pick it up again a few weeks ago ... I can't read their notation/tab for the life of me. It's so confusing. Need to rewire my brain somehow.
Or Yousician. I'm not a fan of the Rocksmith presentation which relies on small position differences and colours, but there are alternatives.