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Or just use poetry/pipenv shell (or poetry/pipenv run for one-off commands). Both provide a good wrapper, although poetry seems a bit more stable these days.

Perl has copied this as well with Carton. Works really well and as standard keeps the modules in the project dir.

https://metacpan.org/pod/Carton

If you prefer "bundle exec foo", then "bin/python -mfoo" is pretty much the equivalent and doesn't require running activate before.