During the cold war all sorts of things were justified because they made sense from the perspective of US (governmental) interests. The Vietnam war, the Mujahideen, the toppling of free and democratic governments. In a "realist" framework, the ends justify the means. The "ends" and "means" here are considered from the point of view of the statesman.
When the world is viewed as a chessboard between competing nations, human beings outside the decision making centers suffer - we are reduced to being expendable resources, collateral damage, in the pursuit of "national" interests.