I don't even oppose Thiel's initiative, I just don't think it has particularly broad implications. If the non-college-attending kids in his program do well, a reasonable conclusion to draw is: if you have someone willing to give you $100k and introduce you to good business connections, in lieu of attending university, then that is quite possibly a good opportunity to take.
If you don't have such an offer, on the other hand...
I'm not sure that needed demonstration.
I personally view this as a publicity stunt. I imagine it cannot be replicated in fields such as mathematics or biochemistry.
It may be fun to watch...
It'd be a whole lot more meaningful to test an alternative education program - maybe get people learning online or doing apprenticeships, something people could actually do without massive sponsorship - and create a credentialing system that's actually selective and credible, so those people aren't at a disadvantage in the job market. Something like that would actually take aim at the prestige of higher education.