My general guess is that anything actually worthwhile will have little to no private funding behind it.
Global heating. Racism. Soil extinction. Fascism. Disenfranchisement. Inequality. Female disempowerment. etc.
I guess there is government cheese for global heating. Not sure how much useful work would be done outside of government-run and/or -funded laboratories.
And anything that could potentially start out as being at least notionally-well-intentioned will come around to being not that.
My general thinking at this point is I have to find or help to create a small, well-organized group of people who start a not-funded social movement that will oppose almost everything most philanthropists and investors and do-gooders actually care about.