That's very interesting!
I remember this happening a lot with sports / nutrition studies. I'm not surprised to see medicine in there as well.
Overall, understanding the brain is hard, understanding our bodies is hard, it's normal that we can come up with a limited amount of consistently reproducible knowledge per year.
From all my friends who pursued STEM, I assume this is happening because of the pressure on people pursuing higher education at all costs, not finding enough qualified jobs, getting stuck in academia and printing low quality papers to get a promotion / keep getting another public grant.
If you add in to the mix results influenced by the current political climate, what your peers think, what your sponsors want to prove for financial gain, the situation gets bleak very fast.
Irreproducible papers are the abandoned OSS projects of software engineers in private tech + corruption + public money, a recipe for disaster.