Gravity.

Overcoming gravity takes a lot of energy, and if you're only moving a relatively short distance it's a huge waste getting a payload in to the air if there's an acceptable alternative.

For long distances fixed wing drones will definitely be better though.

Wheels (if practical) are best. Then legs (or wheel/leg hybrids). Then fixed wing (if you have somewhere you can take off and land). Multirotors are easy and fun but only practical for short missions.

Flying like a quadcopter is more like walking like a cart.