Things like:
The triple-tap-to-zoom feature has a “low light” filter that works on top of your brightness setting so you can use it to get a lower-than-lowest-brightness for reading in bed at night (even the lowest brightness isn’t low enough sometimes).
Reachability setting if you have a big phone and small hands let’s you drag the entire interface down with 1 finger and reach buttons at the top of the UI.
LED Flash for Alerts gives you a visual notification if you work somewhere where you need your phone on silent but also can’t use vibration alerts (she works in a medical field and her phone sits across the room on a table).
Lots of interesting ideas in an area of Settings 99% of people never touch.