My tax-year-end donation in 2019 was at the time my biggest, as I'd completed my 1st year of full-time employment. Hovering on the donate button I definitely felt large reservations as my brain made all sorts of excuses not to send away thousands of dollars that were 'mine'. I felt that it would be helpful to document those reservations so that I could look back on them after years of donating, and I did so here: https://thundergolfer.com/charity/politics/effective-altruis...
After selling some of my stock compensation last month I doubled my previous largest donation, and the reservations were almost completely gone. It'd become obvious that my happiness depended not on that extra money but on all sorts of other non-monetary things, and my safety and health was also obviously protected enough without it.
If I 'napkin-math' the numbers and assume ~6% returns on investment and normal income growth for today's software engineers, over my life my donating will see my net-worth reduced by more than $5 million dollars. But as a young person contemplating today's crises and the crises of our near future I couldn't give less of a shit about being $5 million dollars richer.