When Lightspeed C (renamed to Think C) came out most of the Mac developers I knew that used C switched to it. I was still writing in MPW Pascal, and would continue to use it for professional Mac development until '91.
The C compiler that I remember working with was Aztec C, but for early Mac side projects. Later I switched to Think C for my side projects.
An aside: My first C compiler was for CPM and was named BDS C.
The NIH attitude of the team didn't help the toolset make inroads anywhere. MPW had its own take on Make and a bunch of other Unix-y tools. Basically it was a license to revisit a bunch of hoary, old (even then) utilities, sometimes improving them, sometimes striking out.
My lord, it was slow. It didn't help that the fastest I/O on a Mac back then was a 5Mhz SCSI bus hooked to spinning rust. Builds could take hours. The symbolic debugger was . . . interesting (okay, it was awful).
[I worked on a bunch of its tools, including the linker and some runtime stuff.]
I always figured this was inspired by Smalltalk, with its “DoIt” command, but never asked the MPW folks.