Isn't the Knacksack problem hard and unsolved problem?
Anyway, yes, in the strictest sense of the term, it is unsolved because it's NP-complete, however it's been thoroughly analyzed in many different ways (it's pseudo-P, we have a MITM algo, different flavors of approximations, etc.)
There exist np-complete problems with known super-polynomial, sub-exponential solutions. The stable set problem for planar graphs is an example.