I want to try a 40-key board so I’m trying to make more use of the layers.
Having built an ErgoDox (from the online plans) I regularly use it and have good muscle memory for it. When I switch to a regular keyboard my muscle memory for that other keyboard kicks in and I'm able to use that one fine.
It's actually harder to switch from using my ErgoDox on Windows to the same ErgoDox on Mac because I use the bottom-left key for control on Windows and the bottom-right key for Command on Mac (both on the left-hand-side of the keyboard).
Even that's not too bad, but there is a noticeable 'switch over' time - maybe 5-10 minutes or so.
I had a friend who went full dvorak and had a hell of a time just changing an airline ticket on my machine, though. A big chunk of this article is about relearning typing for new key layouts...
I do have to look at the keys if I'm not using Colemak though.
It takes me half an hour or so to adjust every time I switch machines. The laptop to mechanical isn't so bad, but in particular, the Dell and Lenovo keyboards have different orders of the Function and Control keys, and I constantly enter the wrong key combos if I'm coming from the other laptop. The transition from mechanical keyboard to the rubber ones on machines also leaves me using either too little force to register a key, or slamming my fingertips into the steel backplate at the bottom of travel. And the Fanuc CNCs are high-dollar, highly functional machines, but their keyboards - ugh! Mushy, wobbly, weird row/column spacing and alignment, weird layout... fortunately you can plug in a USB keyboard if you carry one with you, but otherwise I have to slow down to a hunt-and-peck crawl or I make constant typos in an environment where typos can be really expensive.
I do acknowledge that switching from a full size keyboard to a laptop, or from a laptop to a phone keyboard can be pretty smooth. And that the short time adjusting can easily be worth the effort, especially if you're going to be working on a given machine for a few hours. But if they are physically similar and functionally remapped then I don't think I could do it.
So drop the laptop on the doc, use a natural keyboard. Drop it on the desk at home, plug in a keyboard, etc.
Luckily, you can switch easily to Dvorak on most systems for the last couple of decades. Something that's less true once you start inventing your own layouts (though I think Colemak, Neo and Workman are decently suppprted).
Also, people who learned to touch type QWERTY suggest you can swap back even after learning a new layout. I never learned qwerty that well but return to standard nerd level of familiarity.