I wonder if he would be interested in optimizing for purely algorithmic tasks?
There are a lot active and successful CPython and PyPy users on https://atcoder.jp/. For example:
https://atcoder.jp/contests/practice2/submissions?f.Task=&f.... (the user "maspy" is rated at 2750 using only cpython!!!)
https://atcoder.jp/contests/practice2/submissions?f.Task=&f.... (though pypy is more practical)
I am linking to atcoder because their testing data is public so you can rerun contestants solutions using both pyston/cpython/pypy for benchmarking purposes: https://www.dropbox.com/sh/arnpe0ef5wds8cv/AAAk_SECQ2Nc6SVGi...
Right now, other than a handful of people who figured out how to make numba's jit work, only pypy is viable for competitive programming. I wonder if you can do better than pypy?
There are also a few red coders on codeforces.com who mostly use pypy (cpython is completely unviable there because numpy and numba is not installed)
https://codeforces.com/submissions/pajenegod
https://codeforces.com/submissions/conqueror_of_tourist
But codeforces' test cases aren't public anyway so it's not as relevant.