For example, pressing "f" with Vimium should enumerate things that can be clicked(think anchor elements and button elements) but it enumerates nothing on https://gallery.flutter.dev/#/. This is a pretty good proxy for accessibility too i.e. things that can be clicked look like they can be to the machine. A quick document.querySelectorAll('a') and document.querySelectorAll('button') in the console verifies that there are no such elements.
Another one, basic browser features like backswipe on the trackpad to go back just doens't work.
Custom user agent stylesheets is another accessibility/power user feature that will not work
You cannot select any text as far as I can tell
Reader mode doesn’t work, not even on the news demo which is a prime example of where it should work
You cannot copy or preview link URLs
You cannot copy image URLs
Navigating by landmarks(such as headings) probably also doesn’t work(I haven’t tried this yet)