Hacker News Reader

Comment by LinuxBender | Hacker News Reader

This is not a great article. It leaves out Dr. Sinclairs work, further developing discoveries by Dr. Yamanaka specifically around the four transcription factors (Oct3/4, Sox2, Klf4, and c-myc), turning any cells back into pluripotent stem cells. More important, leaving c-myc disabled, the cell reverts to a younger age. This is what Dr. Sinclair has been working on recently, to completely reverse macular degeneration. He has been able to regrow damaged optic nerves all the way from the eye back to the brain.

Here is a talk he did at Google [1] He briefly talks about the ethics of this here [2].

[1] - https://www.youtube.com/watch?v=9nXop2lLDa4

[2] - https://www.youtube.com/watch?v=G4tsELrQfFQ

View on HN

Please note. Dr. Sinclair is 51 years old. As you watch [1], really let that sink in.

Wow. I would have guessed mid-30s from the video?

That's a bit of an exaggeration. I'd put him at his mid-40s. He looks roughly my age. 50 is possible too.

Thing is, you estimate age mostly based on someone's skin, and with clothes on, that means face. It's very superficial. If you've got good skin, you'll look younger. There's a ton of products that will help. There are plenty of celebrities that are older but look younger. (Did you know Cher is 74?)

The most interesting part is really the health benefits: less degradation of various bodily functions, more stamina, better quality of life.

What skincare products do you recommend?

He looks reasonably young for his age but that could very well be genetics as much as sensible living or following his research; though I didn't watch the video far enough to see if there are reasons that is unlikely.

Doesn't prove anything. Could have great genetics, makeup, hair coloring, plastic surgery, etc.

Wow. And then the video above [1] was recorded 1 year ago, while this other video below [3] was recorded 7 years ago.

So 6 years later he looks like 10 years younger. That's the most mind-blowing part.

[3] https://www.youtube.com/watch?v=vCCdmGKtxPA

That's entirely due to TEDxSyndey having poor lighting that cast a shadow on his face.

> He has been able to regrow damaged optic nerves all the way from the eye back to the brain.

I assume the process may be similar to do the same with other cranial nerves? Eg hearing

Oh my god, I would pay good money to recover hearing from the left side!

isn't he all about resveratrol as well?

That was his area of focus about a decade or so ago. It turned out not to be as exciting as many thought it would. There are some benefits to TransResveratrol, but not what people were hoping for. Here is an interview with Dr. Rhonda Patrick and he talks about longevity genes. [1] I believe he covers TransResveratrol here. He also talks about reversing the Horvath Clock and reversing damage to optic nerves.

[1] - https://www.youtube.com/watch?v=5DtWqzalEnc

I too get all my medical advice from the Joe Rogan podcast

You can get it from his books too. I listened to his audio book which was good. Learned quite a bit.

Penrose was on JRE too, they should've not given him the Nobel just based on that.

Why exactly?

I was sarcastically pointing out the parent's ignorance.

Gotcha. Somehow thought there was something wrong with his episode, which I found tremendously interesting.

You don't get advice from Joe, you get it from his guests. Which are notable.

Could you summarize please? I watched that interview and didn't get much out of it, since I perceive R. Patrick as a sensationalist - magic ice baths, magic saunas, magic grape chemicals, etc.

Reply on news.ycombinator.com