I would recommend at least checking out Racket and giving it a chance if you've never even heard of Scheme. If you like Python's syntax, then you might be interested in the Rhombus project that the Racket team is embarking on or Pyret, both of which have Python-esque syntax. I'd also recommend F#, which has just as clean, if not cleaner syntax than Python.

It's hard to call Python's syntax perfection when it is missing piping and pattern matching. Python can't even do multiline method chaining without an extraneous "\" character or parentheses. Python also doesn't have a multiline comment syntax.