Human ageing process biologically reversed in world first | Hacker News Reader

Human ageing process biologically reversed in world first

yahoo.com

21 pointshuntermeyer19 comments

From what I can tell as a complete layman, the title is quite sensationalist: the only process being reversed is telomere lengthening, which has a tenuous relationship with aging at best.

Yes, if researchers had really reversed human ageing, do you really think yahoo.com would be breaking the news?

I don't see what relevance that has to this story. Yahoo.com isn't breaking the news, only reporting about an article published in a journal.

Yeah, you're right. I realized it was a dumb comment after I posted it...

I've actually studied this, and I agree with you. I see a notable difference between "less disease of a very specific sort" and "reversed aging" although the end result is remarkably similar (without the age digression, of course). The article treats them as the same. Unless your sole definition of aging is in re how far down the chain your telomerase shows up.

To me, reversing aging would be more like the Benjamin Button story. But that's not the story being told here.

Depending on how you are looking at it, they're either very similar things, or completely different things. I see them as being very different.

There have been a few interviews with Bret Weinstein on this topic as it pertains to lab mice. [1] [2] I am curious if this is in any way related and would there be similar concerns around how humans deal with senescent cells and cancer if Telomere are artificially lengthened. Out of curiosity, does anyone in this field have more information to add to Bret's interview that can explain technically how the mice ended up with longer Telomere's and if it was on purpose?

[1] - https://www.youtube.com/watch?v=hKTV2R6TT0Y

[2] - https://www.youtube.com/watch?v=ve4q-1D_Ajo

I was unable to find the paper the article claims was published about this, which is a shame because I'd love to learn more about what the researchers actually said. The mechanism described in the Yahoo article is implausible to say the least (TANSTAFFL principle: if you could reverse aging by simply lengthening telomeres, there would have been significant evolutionary pressure for increased expression of telomerase, so unless it came with sufficiently bad downsides, you would expect it to have already reached fixation in the population). Still, I would be interested to see what the researchers themselves actually say.

I did find a related article, titled "Telomere elongation followed by telomere length reduction, in leukocytesfrom divers exposed to intense oxidative stress – Implications for tissueand organismal aging" [1]. I would expect the actual findings here were similar to that article.

[1] http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.208...

> I was unable to find the paper the article claims was published about this, which is a shame because I'd love to learn more about what the researchers actually said.

https://www.aging-us.com/article/103571

I don't think it's that one, no mention of telomeres anywhere in the article.

Here's a book (not an article)

https://www.ncbi.nlm.nih.gov/books/NBK6486/

It's been a while since I looked into this. The (simplified) AAAA at the end of a DNA strand gets shorter and shorter upon each reproduction, kinda like an aglet, holding things together until it is too short, and then the strands unwind and get knotted in counterproductive ways, creating unintentional proteins, etc, resulting in disease and eventually death. Our immune system typically notices this happening, and kills off those cells first. Eventually it gets out of control, and population density is maintained.

Evolution-wise, this kills off the individual sooner. Population-wise this maintains the population strength since it lowers the energy competition (food, etc) and keeps it balanced.

Group selection hypotheses tend not to pan out except in very specific situations where each member of the group shares almost all of its genetic material with other members of the group.

I mentioned that in another comment - it only counts if the individual makes a significant impact on the next generation(s). Hence my original comment about living longer (past reproduction age) not budging the evolutionary aspect.

Evolution has very little to do with individuals. It has everything to do with what gets added or subtracted from the population as a result of its appearance and spread within the population.

Does increased longevity positively affect the success of a population? Evolution is about the population, and pretty much disregards the individual unless that "beneficial" individual makes sweeping positive changes in the next generation. I don't think 80 year olds are reproducing all that often these days, so at least my understanding of how evolution works doesn't apply to this. Aging out of individuals is a way of keeping that balance.

More technically:

In evolutionary computation, there is a specific area focused on scaling. The quick gist is that the warmer and larger an organism is, the more energy is required to keep its population alive. Populations of different organisms tend to use the same amount of energy. This is why you have dense populations of bacteria and ants, but not of elephants and hippos. When that goes awry, parts of one or the other population dies off to keep that balance.

So the more predators there are, the more prey is needed to support the predator population. The models present that the sum of all biological activities in any given population scales with the individual's mass by a power of 3/4. This rule shows up everywhere in nature, except for one.

Humans are the only life form known that violates this principle, and our population is already hyper-dense by a factor of 58,000 times over all other life forms. Domestication of plants and animals (farming) and industrial advances have propelled us beyond that limit.

Living so far beyond reproduction and family-building age is an exercise in the law of diminishing returns.

Oh yeah when I'm talking about evolutionary pressure in that direction I'm referring to the time before agriculture, and probably before language. Definitely not modern civilization -- as a general rule, if you don't see massive differences between human populations in varying regions on a particular metric, you can assume that there hasn't been any strong evolutionary pressure on that attribute in the last few hundred generations (e.g. height varies quite a bit, as does melanin concentration, implying fairly recent selection for those traits, while lifespan is pretty constant given similar access to healthcare, implying that there hasn't been a significant difference in evolutionary pressure from region to region on lifespan).

Additionally, humans have a much longer lifespan than other mammals of similar size, implying that at there was strong evolutionary pressure for increased lifespan around the time humans diverged from other primates, and even a bit before that as other primates also live longer than most mammals their size.

For the most part, yes, then.

Humans have the skill of extrapolation and invention that other animals completely lack, or only barely approach to our level.

Our ability to communicate instantly to other humans on the other side of the world (or even not on this world) is testament to the ways we have overcome certain barriers in natural selection. We literally chirp louder than any bird ever could. Lots of diseases simply wouldn't exist today if we didn't learn how to medicate and operate, because those diseases would have killed off those humans prone to them, and only "immune" humans would survive. Etc.

So in the early days when Homo Sapiens were not the only beings headed towards our modern (evolved) form, there probably were vastly different mortality rates depending almost solely on that scaling equation. There probably still is today, but more or less nature forcibly trying to maintain that 3/4 ratio.

I'm only speaking in re evolution since you mentioned that, because otherwise you're spot on.

- "The pressurised chamber allows more oxygen to be dissolved into the tissues and mimics a state of "hypoxia", or oxygen shortage, which is known to have regenerating effects." This seems counter intuitive, anyone know the mechanism here?

- Did this article fail to link the paper, or am I failing to see the link? Poor reporting if the former.

- There is a gap in reporting here...anyone know exactly how telemeres actually lengthen from this?

- Unrelated: Is anyone in the industry actually interested by Brett Weinstein's supposed involvement in lab mice telemere issue discovery, or is he seen as an irrelevant pest within these circles?

I found the article independently, linked on this reddit thread: https://www.reddit.com/r/longevity/comments/jwnqvu/aging_hyp...

Ah thank you.

Shame - Red flags throughout that paper, albeit some being self identified.

Any time telomeres show up in relation to aging I question it's relevance. I've never seen any causal connection, only correlation. Is there any solid evidence that short telomeres cause aging or that lengthening them actually does anything?

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