Any async or event-loop runtime can be almost entirely powered by io_uring. Timers, waiting for work when you're out of CPU-bound tasks, most IO syscalls, it all can go through io_uring.

You'll still need a few worker threads for blocking syscalls that haven't been ported to io_uring yet but that need is greatly reduced compared to the previous state of things.

So even if you're not using io_uring yourself the language standard libraries or server frameworks will.

There are WIPs for netty, libuv, nginx. Other projects are exploring it or have announced intent to use it.