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Your first sentence is quite tricky to parse due to the triple negative. I parsed it as:

Most people that email you will care if you ignore them.

Is that a... triple negative?

I think you mean senders expect a response?

Do you triage your spam?

What is the false positive ratio, do you think?

My false positive ratio for "spam" marked automatically by gmail is around 50%. It's only that low because I started receiving occasional spam emails; it was more like 90%.

(To be clear, I've interpreted your question as "of emails that got sent to the spam folder, how many of them had no business being in there?")

Let’s play a game, here’s how I would rephrase your first sentence:

You are often not the kind of person who can afford ignoring emails.