I think a lot depends on what you're used to. I think a lot of folks accept the limited mobility they knew through school when they graduate. It becomes less acceptable as they get older. Many exceptions of course.
Is there that much of a difference between owning a car and renting a car or using Zip or having a chauffer (Lyft, Uber, taxis) tote you around? I'd get rid of my car too if I could afford to have Uber haul me everywhere.
With reference to my sibling comment, definitively yes. I personally spent less on a handful of Lyft rides per month in Houston than I did on insurance alone when I owned a car. Never mind the cost of the vehicle itself, gas, any repairs...
Even adding in the cost of my rail and bus rides, still doesn't come close to the cost of a vehicle.
The cost of owning a car in California including maintenance, fuel, parking, registration, smog check, etc. can be upwards of $10K per year. At least it was for me when I owned a car.
I walk most places and use car share or rent as necessary. I do not spend $10K per year on car share and rentals.
Literally, YMMV.
It's a difference in frequency of use. In Seattle, a lot of my friends don't have cars, but use Rideshare/rentals when they need it. If you are using it a couple times a week, pretty easy to stay under the cost of car ownership when you factor in insurance/parking/maintenance etc.
Within Midtown, the further North you go, there are a few more bars/clubs that make noise at night, so either live further South, live a few blocks East or West of the rail, or both. Huge amounts of apartment stock just came online in the last 3 years there, so you might get a solid rent deal somewhere? For me personally, being able to walk to a grocery store is always key anywhere in the world: shop every 2-3 days on the way home from work, only buy what I need, less waste. That area has two grocery stores: Randall's and Whole Foods.
Montrose is the other top spot. For me it is the #1 example of how Houston's lack of zoning can shine (versus other areas where it is a detriment). Fantastic local retail interspersed among every-other residential block. Montrose is a large-ish area and every half mile can be a slightly different "feel", but there are great options to rent newer apartments, older apartments, or rent spacious, cheap, historical houses close to things like Menil Park, or the big restaurant scene along Westheimer. Sadly the Kroger at Hawthorne is closing, but the huge HEB is dead-center of Montrose. East a bit and you're near Trader Joe's. If you're anywhere along Westheimer, the 82 bus goes to to Midtown Whole Foods and if you're along West Gray the 32 bus goes to the Kroger near River Oaks. The whole area always has things happening (check the pinboards at Inversion or Black Hole), and is next door to Midtown for even more.
If Downtown would get a larger grocery store with slightly more affordable staples (no offense to Phoenecia), and have it close-ish to where the rail lines meet, the entirety of Downtown would immediately become more viable (imo). I have friends both in Downtown, and in the Heights (solid bike culture there), but they eat out more than I do. The Heights started getting expensive ten years ago and doesn't look to stop, but it's still an option.
In about 5 years I think the Greater East End will be another great walkable/bikeable region (the actual East End, not EaDo), so depending where along the gentrification curve you prefer to live (before, during, after) it might be worth checking out now.