Sort of. If the Pais effect is described in enough detail, such that an "ordinary" person of "skill in the [technical field relevant to the making or using of the invention]" can use the teachings of the patent in combination with what is already commonly known to practice the invention without "undue experimentation", then the patent is considered enabled. If the patent does not teach enough to meet this criteria, then it is invalid for non-enablement. One subset of non-enablement is that the "invention" is simply not possible (e.g., perpetual motion machine).

Can’t patent physical laws, natural phenomena, etc.