I think it's in part related to fractional scaling, which hasn't been sorted everywhere. Text at 4k on a 27 inch is too small to run at 100%, too much of a waste to run run at 200% (equivalent to 1920x1080). So you're running 150% or 175% and that can be an issue if you're running something that doesn't like fractional scaling.
27 inch is perfect for 1440p 100% or 200% (i.e., 5k), but it seems like no one other than Apple has that figured out.