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Loperamide can also be cardiotoxic at high dosages [1] which is, I believe, rare among opiods but I am not a doctor. (Googling "morphine cardiotoxicity" is showing me an almost equal amount of articles claiming it causes and protects against. Again, not a doctor.)

[1] https://www.sciencedirect.com/science/article/abs/pii/S07356...

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I haven't heard of morphine being generally cardioprotective, but I'm no cardiologist. It's routinely given during heart attacks because it reduces cardiac demand, so it reduces the heart tissue that dies due to lack of oxygen during the heart attack. But that's all I really know on that one.

I spent all of 30 seconds vetting that information, alologies. Here are the two article titles I am basing that off. Should have said protective against cardiotoxicity in some specific circumstances, maybe. Didnt mean to imply it's heart healthy like cheerios and alcohol.

"Morphine is protective against doxorubicin-induced cardiotoxicity in rat" https://pubmed.ncbi.nlm.nih.gov/17988779/

"Morphine enhances doxorubicin-induced cardiotoxicity in the rat" https://pubmed.ncbi.nlm.nih.gov/24531975/

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