3-5 years ago, the most effective way to design campaigns was by micro-targeting audiences. That is, you would have thousands of adsets, and each adset would target a small slice of your target audience.
The theory behind micro-targeting was that your audience's conversion rate varies considerably by certain key targeting attributes. And, if your audience has varying conversion rates, your CPC bids ought to reflect this.
For example, let's assume your LTV is $100. And, let's assume your average conversion rate is 1%, but actually, males convert at 0.5% and females convert at 1.5%. If you do NOT split your audience by gender, you will be forced to bid $1 per click for every user. However, if you split your audience by gender, you can bid $0.5 for men and $1.5 for females. By splicing your audience, you gain considerable efficiency. The theory behind micro-targeting was to find the permutations of targeting attributes that split your audience into segments with the most variance in conversion rates.
However, what's happened over the past few years is that Facebook's AI has become vastly better at doing micro-targeting than even the best individual marketers. This is partly because they have more data than platform participants, but also because they have much smarter engineers. As a result, it's now become better to hand over targeting responsibilities to Facebook's AI. For the most part, you just tell them what you want the average CPA to be, and they do the targeting for you behind the scenes.