Dungeon Keeper comes to mind as a game that starts to go in that direction but it can be argued it is more a (very) fun management game than an RTS.
Probably not doable, we would lose a lot of expressivity in such a change. However, if there is a new RTS coming, I personally would love to see an innovative take on the genre, closer to Brutal Legends 2 / Sacrifice 2 (or as another commented posted, something emulating logistics would be another interesting avenue) than to the inevitable Warcraft 4 (for ios ;)).