The problem isn't feasibility, it's resources. Building and rolling out a standardized environment, and maintaining it, will cost millions of dollars. It shouldn't, but it does. And for what added benefit? The end-users don't want it, you'd have to spend another couple million for a lateral move at best. More than likely, you'll end up with a pile of Python spaghetti code that runs slower than the spreadsheet (see point #4 about massively recursive calcs).