I remember Sun's "Lively Kernel" project. It looks like this has some of that DNA in it. I can't claim to have ever bent my brain to quite grok Smalltalk-and-attendant-tools, but I definitely appreciate its contribution to our software heritage and see traces of it all around, especially in the NeXT/Apple ecosystem.
I think that Lively Kernel has huge potential to influence the current web. When you consider something like how this site (HN) operates, and could be implemented using something like the LK, perhaps we can start programming interactive systems better than we do.
Note that the Lively Kernel dates from 2007 (!) -- development continues to be supported by the Hasso-Plattner institute in Potsdam, Germany. https://lively-next.org/
You can't really do a like-for-like comparison. I encourage you to check out Pharo or Squeak, and at least do the intro tutorial, to see the difference for yourself.
That's not to be elitist, it's just really worth trying out.