The computer running universe-simulations needs to be able to run fast. Regularities can be integrated quickly. Life not so much.
Life can make computers which can ask computations which can't be reduced.
Therefore as soon as a big enough computer is built somewhere in the universe, the whole simulation-time starts crawling to an halt because the inner computer use all the resources, and future times in the universe where there are many of those computers never get to be materialized.
Alternatively, solutions using time-travel allows to run simulations of longer simulation-time, by introducing a time-coherence force which prevent such computer (aka biological-numerical instabilities) to ever emerge.