At least as far what I've gathered reading airliner crash reports go (these obviously are going to be skewed) one of the challenges seems to be just being up to date / adjusting from one airliner to the next as far as procedure, and recovery processes for a given aircraft.

Being behind the aircraft as far as interpreting the situation/ indicators and not knowing what recovery steps to take seem to be a reoccurring problem, at least as far as catastrophic type situations.