With DOS emulator.
There is no problem to run DOS app from 80s on Linux/MacOS/whatever with dosbox. By the way, dosbox is far better for some apps than DOS emulator from Windows XP/Vista/7.
read the Raymond Chen blog about how they used SimCity as a benchmark to test if their backwards compat was working. Marc Andreessen is even on the record as being an admirer of the Windows backwards compat work. they put a lot of work into it and placed a high value on it because they did not want to break developer trust.